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ccug 37002 serotype b  (ATCC)
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Ccug 37002 Serotype B, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ywhab #pa1-37002 antibody  (Thermo Fisher)
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<t>YWHAB</t> depletion promotes YAP activity in OCPM. (A) The mRNA levels of YAP in YWHAB-knockdown CR primary OCPM and OVCAR3 cells and their control cells were measured by quantitative reverse-transcription PCR assay (one-way ANOVA; n = 3 biological replicates). (B) The protein levels of whole cell YAP and phosphorylated YAP in YWHAB-knockdown and control cells were measured by Western blot assay (one-way ANOVA; n = 3 biological replicates). (C, D) The protein levels of cytoplasmic (C) and nuclear (D) YAP in indicated cells were measured by Western blot (one-way ANOVA; n = 3 biological replicates). (E) The heatmap representing the relative mRNA levels of indicated YAP target genes in YWHAB-knockdown and control cells. (F) The transcriptional activities of YAP in indicated cells were examined by luciferase reporter assay (one-way ANOVA; n = 3 biological replicates). (G) The abundances of YAP and pan-TEAD immunoprecipitated by pan-TEAD antibody in indicated cells were examined by Western blot (one-way ANOVA; n = 3 biological replicates). ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
Ywhab #Pa1 37002 Antibody, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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antibody ywhab #pa1-37002  (Thermo Fisher)
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Thermo Fisher antibody ywhab #pa1-37002
<t>YWHAB</t> depletion promotes YAP activity in OCPM. (A) The mRNA levels of YAP in YWHAB-knockdown CR primary OCPM and OVCAR3 cells and their control cells were measured by quantitative reverse-transcription PCR assay (one-way ANOVA; n = 3 biological replicates). (B) The protein levels of whole cell YAP and phosphorylated YAP in YWHAB-knockdown and control cells were measured by Western blot assay (one-way ANOVA; n = 3 biological replicates). (C, D) The protein levels of cytoplasmic (C) and nuclear (D) YAP in indicated cells were measured by Western blot (one-way ANOVA; n = 3 biological replicates). (E) The heatmap representing the relative mRNA levels of indicated YAP target genes in YWHAB-knockdown and control cells. (F) The transcriptional activities of YAP in indicated cells were examined by luciferase reporter assay (one-way ANOVA; n = 3 biological replicates). (G) The abundances of YAP and pan-TEAD immunoprecipitated by pan-TEAD antibody in indicated cells were examined by Western blot (one-way ANOVA; n = 3 biological replicates). ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
Antibody Ywhab #Pa1 37002, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/antibody ywhab #pa1-37002/product/Thermo Fisher
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200223542 shgq  (Addgene inc)
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Addgene inc 200223542 shgq
<t>YWHAB</t> depletion promotes YAP activity in OCPM. (A) The mRNA levels of YAP in YWHAB-knockdown CR primary OCPM and OVCAR3 cells and their control cells were measured by quantitative reverse-transcription PCR assay (one-way ANOVA; n = 3 biological replicates). (B) The protein levels of whole cell YAP and phosphorylated YAP in YWHAB-knockdown and control cells were measured by Western blot assay (one-way ANOVA; n = 3 biological replicates). (C, D) The protein levels of cytoplasmic (C) and nuclear (D) YAP in indicated cells were measured by Western blot (one-way ANOVA; n = 3 biological replicates). (E) The heatmap representing the relative mRNA levels of indicated YAP target genes in YWHAB-knockdown and control cells. (F) The transcriptional activities of YAP in indicated cells were examined by luciferase reporter assay (one-way ANOVA; n = 3 biological replicates). (G) The abundances of YAP and pan-TEAD immunoprecipitated by pan-TEAD antibody in indicated cells were examined by Western blot (one-way ANOVA; n = 3 biological replicates). ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
200223542 Shgq, supplied by Addgene inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/200223542 shgq/product/Addgene inc
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fkn16 sequence  (ATCC)
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<t>YWHAB</t> depletion promotes YAP activity in OCPM. (A) The mRNA levels of YAP in YWHAB-knockdown CR primary OCPM and OVCAR3 cells and their control cells were measured by quantitative reverse-transcription PCR assay (one-way ANOVA; n = 3 biological replicates). (B) The protein levels of whole cell YAP and phosphorylated YAP in YWHAB-knockdown and control cells were measured by Western blot assay (one-way ANOVA; n = 3 biological replicates). (C, D) The protein levels of cytoplasmic (C) and nuclear (D) YAP in indicated cells were measured by Western blot (one-way ANOVA; n = 3 biological replicates). (E) The heatmap representing the relative mRNA levels of indicated YAP target genes in YWHAB-knockdown and control cells. (F) The transcriptional activities of YAP in indicated cells were examined by luciferase reporter assay (one-way ANOVA; n = 3 biological replicates). (G) The abundances of YAP and pan-TEAD immunoprecipitated by pan-TEAD antibody in indicated cells were examined by Western blot (one-way ANOVA; n = 3 biological replicates). ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
Fkn16 Sequence, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fkn16 sequence - by Bioz Stars, 2026-02
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fkn16 phage vector  (ATCC)
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ATCC fkn16 phage vector
<t>YWHAB</t> depletion promotes YAP activity in OCPM. (A) The mRNA levels of YAP in YWHAB-knockdown CR primary OCPM and OVCAR3 cells and their control cells were measured by quantitative reverse-transcription PCR assay (one-way ANOVA; n = 3 biological replicates). (B) The protein levels of whole cell YAP and phosphorylated YAP in YWHAB-knockdown and control cells were measured by Western blot assay (one-way ANOVA; n = 3 biological replicates). (C, D) The protein levels of cytoplasmic (C) and nuclear (D) YAP in indicated cells were measured by Western blot (one-way ANOVA; n = 3 biological replicates). (E) The heatmap representing the relative mRNA levels of indicated YAP target genes in YWHAB-knockdown and control cells. (F) The transcriptional activities of YAP in indicated cells were examined by luciferase reporter assay (one-way ANOVA; n = 3 biological replicates). (G) The abundances of YAP and pan-TEAD immunoprecipitated by pan-TEAD antibody in indicated cells were examined by Western blot (one-way ANOVA; n = 3 biological replicates). ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
Fkn16 Phage Vector, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fkn16 phage vector/product/ATCC
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fkn16 phage vector - by Bioz Stars, 2026-02
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YWHAB depletion promotes YAP activity in OCPM. (A) The mRNA levels of YAP in YWHAB-knockdown CR primary OCPM and OVCAR3 cells and their control cells were measured by quantitative reverse-transcription PCR assay (one-way ANOVA; n = 3 biological replicates). (B) The protein levels of whole cell YAP and phosphorylated YAP in YWHAB-knockdown and control cells were measured by Western blot assay (one-way ANOVA; n = 3 biological replicates). (C, D) The protein levels of cytoplasmic (C) and nuclear (D) YAP in indicated cells were measured by Western blot (one-way ANOVA; n = 3 biological replicates). (E) The heatmap representing the relative mRNA levels of indicated YAP target genes in YWHAB-knockdown and control cells. (F) The transcriptional activities of YAP in indicated cells were examined by luciferase reporter assay (one-way ANOVA; n = 3 biological replicates). (G) The abundances of YAP and pan-TEAD immunoprecipitated by pan-TEAD antibody in indicated cells were examined by Western blot (one-way ANOVA; n = 3 biological replicates). ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.

Journal: Genes & Diseases

Article Title: Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis

doi: 10.1016/j.gendis.2025.101519

Figure Lengend Snippet: YWHAB depletion promotes YAP activity in OCPM. (A) The mRNA levels of YAP in YWHAB-knockdown CR primary OCPM and OVCAR3 cells and their control cells were measured by quantitative reverse-transcription PCR assay (one-way ANOVA; n = 3 biological replicates). (B) The protein levels of whole cell YAP and phosphorylated YAP in YWHAB-knockdown and control cells were measured by Western blot assay (one-way ANOVA; n = 3 biological replicates). (C, D) The protein levels of cytoplasmic (C) and nuclear (D) YAP in indicated cells were measured by Western blot (one-way ANOVA; n = 3 biological replicates). (E) The heatmap representing the relative mRNA levels of indicated YAP target genes in YWHAB-knockdown and control cells. (F) The transcriptional activities of YAP in indicated cells were examined by luciferase reporter assay (one-way ANOVA; n = 3 biological replicates). (G) The abundances of YAP and pan-TEAD immunoprecipitated by pan-TEAD antibody in indicated cells were examined by Western blot (one-way ANOVA; n = 3 biological replicates). ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.

Article Snippet: The following antibodies were used: YWHAB (#PA1-37002, ThermoFisher Scientific, 1:2000), β-actin (#4970, Cell Signaling Technology, 1:4000), YAP (#14074, Cell Signaling Technology, 1:2500), phosphorylated YAP (#13008, Cell Signaling Technology, 1:2500), Lamin B1 (#13435, Cell Signaling Technology, 1:4000), and Pan-TEAD (#13295, Cell Signaling Technology, 1:4000).

Techniques: Activity Assay, Knockdown, Control, Reverse Transcription, Western Blot, Luciferase, Reporter Assay, Immunoprecipitation

SH3 domain in YAP is critical for YAP-YWHAB binding. (A) The binding between YWHAB and YAP was predicted by in silico analysis. (B) The binding amino acids of the YWHAB/YAP complex predicted by in silico analysis. (C) The bindings between YWHAB and wt-YAP-FLAG and mut-YAP-FLAG with depletion of amino acids 261 to 279 were analyzed by co-immunoprecipitation assay. One-way ANOVA; n = 3; ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.

Journal: Genes & Diseases

Article Title: Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis

doi: 10.1016/j.gendis.2025.101519

Figure Lengend Snippet: SH3 domain in YAP is critical for YAP-YWHAB binding. (A) The binding between YWHAB and YAP was predicted by in silico analysis. (B) The binding amino acids of the YWHAB/YAP complex predicted by in silico analysis. (C) The bindings between YWHAB and wt-YAP-FLAG and mut-YAP-FLAG with depletion of amino acids 261 to 279 were analyzed by co-immunoprecipitation assay. One-way ANOVA; n = 3; ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.

Article Snippet: The following antibodies were used: YWHAB (#PA1-37002, ThermoFisher Scientific, 1:2000), β-actin (#4970, Cell Signaling Technology, 1:4000), YAP (#14074, Cell Signaling Technology, 1:2500), phosphorylated YAP (#13008, Cell Signaling Technology, 1:2500), Lamin B1 (#13435, Cell Signaling Technology, 1:4000), and Pan-TEAD (#13295, Cell Signaling Technology, 1:4000).

Techniques: Binding Assay, In Silico, Co-Immunoprecipitation Assay

The schematic diagram of the mechanism underlying OCPM stemness and resistance maintenance mediated by YWHAB restriction. Down-regulation of YWHAB in OCPM-SCs attenuates YAP cytoplasmic retention and promotes YAP nuclear accumulation, thereby strengthening YAP-mediated OCPM stemness and resistance.The figure was created using BioRender (www.biorender.com).

Journal: Genes & Diseases

Article Title: Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis

doi: 10.1016/j.gendis.2025.101519

Figure Lengend Snippet: The schematic diagram of the mechanism underlying OCPM stemness and resistance maintenance mediated by YWHAB restriction. Down-regulation of YWHAB in OCPM-SCs attenuates YAP cytoplasmic retention and promotes YAP nuclear accumulation, thereby strengthening YAP-mediated OCPM stemness and resistance.The figure was created using BioRender (www.biorender.com).

Article Snippet: The following antibodies were used: YWHAB (#PA1-37002, ThermoFisher Scientific, 1:2000), β-actin (#4970, Cell Signaling Technology, 1:4000), YAP (#14074, Cell Signaling Technology, 1:2500), phosphorylated YAP (#13008, Cell Signaling Technology, 1:2500), Lamin B1 (#13435, Cell Signaling Technology, 1:4000), and Pan-TEAD (#13295, Cell Signaling Technology, 1:4000).

Techniques: